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This comprehensive work explores the pharmacology and toxicology of Dienogest, detailing its chemical structure and experimental endocrinological studies. It examines the hormonal effects of Dienogest in cellular test systems and investigates its pharmacokinetics and biotransformation across various animal species, as well as by microorganisms. The pharmacological and toxicological profile is assessed, including its initiating efficacy in bioassays and studies conducted on primates. The clinical section focuses on the pharmacokinetics of Dienogest, both as a standalone treatment and in combination with Ethinylestradiol. It includes binding studies with various receptor and serum proteins, the impact of Dienogest on calcium influx in human vascular cell cultures, and its influence on the human cytochrome P-450 enzyme system. Comparative studies evaluate the effects of Ethinylestradiol-containing contraceptives with Dienogest versus Levonorgestrel on cytochrome P-450 function in vivo. Further investigations cover Dienogest's effects on ovulation and other endocrine parameters in young women, alongside pilot studies on contraceptive safety, cycle stability, and tolerability. Long-term studies assess the impact of various contraceptives on women's vocal function and document the antiandrogenic effects of Dienogest. The treatment of endometriosis with Dienogest is also discussed, highlighting its receptor status and the renaissan
Achat du livre
Dienogest, Alexander T. Teichmann
- Langue
- Année de publication
- 1995
- product-detail.submit-box.info.binding
- (rigide),
- État du livre
- Bon
- Prix
- 4,79 €
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- Titre
- Dienogest
- Sous-titre
- Präklinik und Klinik eines Gestagens - 2. Auflage
- Langue
- Allemand
- Auteurs
- Alexander T. Teichmann
- Éditeur
- de Gruyter
- Publié
- 1995
- Format
- rigide
- Pages
- 292
- ISBN10
- 3110150859
- ISBN13
- 9783110150858
- Séries
- Description
- This comprehensive work explores the pharmacology and toxicology of Dienogest, detailing its chemical structure and experimental endocrinological studies. It examines the hormonal effects of Dienogest in cellular test systems and investigates its pharmacokinetics and biotransformation across various animal species, as well as by microorganisms. The pharmacological and toxicological profile is assessed, including its initiating efficacy in bioassays and studies conducted on primates. The clinical section focuses on the pharmacokinetics of Dienogest, both as a standalone treatment and in combination with Ethinylestradiol. It includes binding studies with various receptor and serum proteins, the impact of Dienogest on calcium influx in human vascular cell cultures, and its influence on the human cytochrome P-450 enzyme system. Comparative studies evaluate the effects of Ethinylestradiol-containing contraceptives with Dienogest versus Levonorgestrel on cytochrome P-450 function in vivo. Further investigations cover Dienogest's effects on ovulation and other endocrine parameters in young women, alongside pilot studies on contraceptive safety, cycle stability, and tolerability. Long-term studies assess the impact of various contraceptives on women's vocal function and document the antiandrogenic effects of Dienogest. The treatment of endometriosis with Dienogest is also discussed, highlighting its receptor status and the renaissan