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The Response of E. coli to the Biocide Polyhexamethylene Biguanide

The molecular stress response to PHMB suggests interaction with nucleic acids is crucial for biocidal activity.

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Michael Allen

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Pages: 364pages
Temps de lecture: 13heures

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The study investigates the effects of polyhexamethylene biguanide (PHMB) on E. coli, revealing its dual bacteriostatic and bactericidal properties based on concentration. Analysis of transcriptional and protein profiles indicates that exposure to PHMB alters gene expression related to membrane functions and cytoplasmic processes. Notably, the research highlights the induction of DNA and protein damage responses, suggesting PHMB's impact extends beyond the cell envelope into the cytoplasm, where it binds to nucleic acids and influences their precipitation.

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The Response of E. coli to the Biocide Polyhexamethylene Biguanide, Michael Allen

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Année de publication: 2010
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Titre: The Response of E. coli to the Biocide Polyhexamethylene Biguanide
Sous-titre: The molecular stress response to PHMB suggests interaction with nucleic acids is crucial for biocidal activity.
Langue: Anglais
Auteurs: Michael Allen
Éditeur: LAP LAMBERT Academic Publishing
Publié: 2010
Format: souple
Pages: 364
ISBN13: 9783838373874
Mots clés: Sciences naturelles, Biologie
Description: The study investigates the effects of polyhexamethylene biguanide (PHMB) on E. coli, revealing its dual bacteriostatic and bactericidal properties based on concentration. Analysis of transcriptional and protein profiles indicates that exposure to PHMB alters gene expression related to membrane functions and cytoplasmic processes. Notably, the research highlights the induction of DNA and protein damage responses, suggesting PHMB's impact extends beyond the cell envelope into the cytoplasm, where it binds to nucleic acids and influences their precipitation.