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Focusing on advancements in organic chemistry, this thesis introduces a novel methodology for the asymmetric synthesis of lactones, crucial components of many natural products, leading to the creation of biologically active analogues. Additionally, it details the development of a catalytic asymmetric synthesis for a key structural motif found in various natural products and pharmaceuticals. A significant finding of dual stereo control was achieved, enabling the configuration of a new stereo center through a straightforward alteration of the proton source.
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Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones, Robert Doran
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- Année de publication
- 2015
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