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- 152pages
- 6 heures de lecture
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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Langue
- Année de publication
- 2012
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- Titre
- Heteroaromatic Lipoxin A4 Analogues
- Sous-titre
- Synthesis and Biological Evaluation
- Langue
- Anglais
- Auteurs
- Colm Duffy
- Éditeur
- Springer Berlin Heidelberg
- Publié
- 2012
- Format
- rigide
- Pages
- 152
- ISBN13
- 9783642246319
- Séries
- Springer Theses
- Mots clés
- Nonfiction
- Description
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.