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Focusing on confirmatory adaptive designs, this book offers a comprehensive review of their principles and techniques, emphasizing their evolution from group sequential designs. It details the process of conducting interim analyses to potentially halt trials while managing Type I error rates. Additionally, the text covers the flexibility of adaptive designs, allowing for data-driven modifications such as reassessing sample sizes, selecting treatment arms, or identifying specific sub-populations during the study.
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Group Sequential and Confirmatory Adaptive Designs in Clinical Trials, Gernot Wassmer, Werner Brannath
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- Année de publication
- 2016
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