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Cell Biology

Enhanced Digital Version Included - Fourth Edition

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This reader-friendly edition offers a concise yet comprehensive foundation for students pursuing careers in research or health care. With award-winning illustrations, it helps readers quickly grasp essential principles. The text has been thoroughly updated to reflect current understanding of normal cellular function and how molecular defects contribute to human disease. Key new themes include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, as well as the influence of new molecular structures and advanced methods like single-cell RNA sequencing and second-generation super-resolution fluorescence microscopy. Clear explanations outline how cells function at the molecular level, beginning with genome organization, gene expression, and RNA processing to provide a solid foundation for understanding cellular physiology. The book illustrates how gene mutations can compromise cellular systems and predispose individuals to diseases, leading to new treatments for conditions such as cancer and cystic fibrosis. Unique illustrations depict critical cellular processes, including DNA replication, synaptic transmission, and the assembly of SARS CoV-2. It also covers breakthroughs like SMC motor proteins organizing chromosomal DNA, TOR kinases regulating metabolism, and mechanisms of cell division and death. An enhanced eBook version is included, providing access to all text, figures, and referen