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This book offers insights into best practices and innovative approaches for validating alternative methods in toxicity testing. It addresses both experimental and computational methods, as well as integrated testing and assessment strategies. The validation of cutting-edge technologies, such as tissue-on-a-chip systems, stem cells, and transcriptomics, is discussed, along with pathway-based toxicology concepts. The content is structured into two sections: the first provides practical insights into state-of-the-art methods that have been successfully validated and accepted, while the second examines the evolution of validation principles necessary for achieving impactful international regulatory acceptance. As scientific advancements in toxicology continue to progress, the book emphasizes the need for validation to adapt to new tools and techniques, alongside growing societal and regulatory demands for improved safety assessments. This resource is valuable for toxicology scientists in both industry and academia, as well as governmental and regulatory authorities seeking to understand the principles and practicalities of validating alternative toxicity testing methods.
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Validation of Alternative Methods for Toxicity Testing, Chantra Eskes
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- Année de publication
- 2018
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