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Continuous advancements in technology and insights into the complexities of neurological diseases have heightened the need for proteomic technologies that can provide potential biomarkers for better clinical management and drug development. This volume outlines the use of proteomic methods, including two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS), and selective reaction monitoring MS, aimed at enhancing our understanding of these diseases to ultimately improve patient care. It will appeal to clinical scientists, physicians, and pharmaceutical researchers by offering insights into the latest technologies that support the evolution of personalized medicine. Additionally, it provides detailed protocols for technical and bench biomarker scientists, making it a valuable resource for researchers as well. Each technique is presented in the context of specific neurological disorders, such as Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder, and bipolar disorder. The volume also emphasizes future research efforts focused on adapting proteomic platforms into handheld devices for point-of-care diagnostics, enabling timely results during routine medical visits.
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Proteomic Methods in Neuropsychiatric Research, Paul C. Guest
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- Année de publication
- 2018
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