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This book presents effective catalytic reactions, emphasizing process intensification, sustainability, waste reduction, and innovative methods crucial for producing pharmaceutically active molecules. It highlights key catalytic reactions and efficient processes, showcasing their advantages over traditional methods. A strong focus is placed on asymmetric catalytic reactions, continuous manufacturing processes, and supported catalysis. Chapters include topics such as the prerequisites for the modern pharmaceutical industry, catalytic process design from an industrial perspective, and various catalytic reactions, including hydrogenation, hydroformylation, oxidation, addition, cross-coupling, metathesis, cycloaddition, cyclopropanation, C-H insertion, phase transfer catalysis, and biocatalysis. The book provides an updated view of the catalysis landscape for API production, focusing on the application of catalytic methods for synthesizing known APIs. It covers key reactions like Diels-Alder and metal-catalytic coupling, and includes recent patent literature for thoroughness. This resource is essential for synthetic chemists and R&D researchers in the pharmaceutical industry, making it a must-read for those involved in API synthesis.
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Active pharmaceutical ingredients in synthesis, Anthony J. Burke
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- Année de publication
- 2018
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