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Volume 18, titled Metallo-Drugs: Development and Action of Anticancer Agents, focuses on biological and medicinal inorganic chemistry. It highlights the landmark discovery of cisplatin's antitumor activity by Barnett Rosenberg in the 1960s, which paved the way for metallodrug-based chemotherapy. Following the clinical success of cisplatin, oxaliplatin, and carboplatin, research has shifted toward polynuclear platinum complexes and Pt(IV) prodrugs due to issues like resistance and toxicity. This has spurred investigations into other metal ions, including Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III), as well as essential metal ions such as Fe(II/III), Cu(I/II), and Zn(II). The interactions between diverse complexes and biomolecules—like nucleic acids, proteins, and carbohydrates—are explored for their potential anticancer effects. The book summarizes cutting-edge research in medicinal inorganic chemistry, presenting next-generation anticancer drugs in 17 chapters authored by 39 experts from 10 countries. With over 2700 references, nearly 150 illustrations (more than half in color), and comprehensive tables, this work serves as an essential resource for scientists across various fields, including enzymology, material sciences, biochemistry, and medicine, while also providing valuable educational insights.
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Metallo-Drugs: development and action of anticancer agents, Astrid Sigel
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- Année de publication
- 2018
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