Tat-translocase composition in Corynebacterium glutamicum and the effect of TorD coexpression

Auteurs

• Dan Oertel

Paramètres

• Manuels
• Manuels universitaires

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White biotechnology utilizes microorganisms or microbial-derived enzymes to produce valuable chemicals, playing a crucial role in addressing the challenges of a growing global population and the increasing demand for fine chemicals, food additives, and pharmaceuticals. This approach offers bio-based production solutions that are independent of fossil fuels, making them more sustainable and generating less hazardous waste. The biotechnological production of proteins and peptides has gained significant importance, with the market for industrial enzymes projected to grow from approximately US$ 3.3 billion in 2010 to US$ 4.4 billion by 2015. Technical enzymes are now widely used across various industries, such as amylases, xylanases, and lipases in baking; pectinases and cellulases in fruit and wine processing; and amylases and cellulases in textiles, often produced by Bacillus species and fungi like Aspergillus and Trichoderma. Additionally, pharmaceutical products like recombinant human insulin, produced in Escherichia coli, and human Interferon in Bacillus subtilis, are in high demand. The direct secretion of desired polypeptides into culture supernatants, achievable with Gram-positive secretion hosts like Bacillus and Corynebacterium glutamicum, enhances downstream processing efficiency.

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• Année de publication: 2014