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To meet the increasing demand for enantiopure compounds, heterogeneous, homogeneous, and enzymatic catalysis have developed independently. While all three methods have produced viable industrial processes, homogeneous and enzymatic catalysis are more widely used and often complement each other. Despite advancements in structural and mechanistic studies, a universal method for optimizing catalytic processes remains elusive, leading to a predominant trial-and-error approach in catalyst discovery. Recently, organocatalysis and artificial metalloenzymes have gained attention as complementary fields. Artificial metalloenzymes are created by combining an active but unselective organometallic component with a macromolecular host. Although the concept was proposed by Kaiser and Whitesides in the late 1970s, the belief that proteins and organometallic catalysts were incompatible hindered research at the intersection of homogeneous and enzymatic catalysis. Since 2000, interest in artificial metalloenzymes for enantioselective catalysis has surged. This work presents the current state of the art and future prospects across five well-structured chapters, with G. Roelfes, B. Feringa, and others summarizing research that utilizes DNA as a macromolecular host for enantioselective catalysis.
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Bio-inspired Catalysts, Thomas R. Ward
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- Année de publication
- 2014
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