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Pheochromocytomas are rare, primarily benign tumors of the adrenal medulla that cause symptoms through the secretion of catecholamines. This book offers a comprehensive overview of the clinical aspects, diagnosis, and treatment of the disease, alongside a detailed discussion of recent advancements in its molecular basis, including new molecular biology tools. Accurate endocrine diagnosis relies on a thorough understanding of tumor metabolism of catecholamines and their metabolites, utilizing highly sensitive and specific laboratory methods. As about 25% of these tumors occur in familial contexts—such as multiple endocrine neoplasia type 2, von Hippel-Lindau syndrome, neurofibromatosis type 1, or familial paragangliomas—genetic diagnosis is becoming increasingly important. Imaging techniques like 123I-MIBG scintigraphy and octreotide scintigraphy are vital for evaluating malignant tumors. Surgical treatment is tailored to the disease's nature, with a lateral endoscopic approach for sporadic unilateral and familial bilateral pheochromocytomas. For malignant cases, treatment primarily involves nuclear medical techniques and targeted chemotherapy. This book is crucial for clinicians and researchers in endocrinology, oncology, surgery, and nuclear medicine.
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Pheochromocytoma, Hendrik Lehnert
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- Année de publication
- 2004
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