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The discovery of penicillin, antibiotics, and insulin sparked a surge in microbiological and bioengineering research focused on utilizing biological systems, such as microorganisms and animal tissue, for producing valuable products. Recognizing the commercial potential of these bioproducts, chemical and pharmaceutical companies invested millions in research and development, as well as in building production facilities. Despite limited understanding of the molecular mechanisms behind product formation, early successes in fermentation and biological extraction paved the way for further advancements. Research and development in both industry and academia aimed at enhancing production processes, particularly microbial productivity and downstream processing, yielded quick returns on investment and maintained market competitiveness. Initial efforts concentrated on discovering high-yield strains for products like antibiotics, generating substantial expertise that extended biotechnological applications beyond pharmaceuticals. This rapid accumulation of knowledge and technological advancements in microbial genetics, coupled with improvements in nucleotide chemistry, significantly enhanced understanding of intracellular processes, laying the groundwork for modern molecular biology and recombinant biotechnology.
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Proteomics of microorganisms, Michael Hecker
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- Année de publication
- 2003
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