Calcium binding proteins in the human developing brain

Auteurs

• Norbert Ulfig

Paramètres

• Santé & Médecine

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This comprehensive review explores calcium-binding proteins (CaBPs) in the developing and mature central nervous system. It begins with an introduction to CaBPs and their significance in brain development. The subsequent sections delve into specific regions of the cerebral cortex, including the subplate and cortical plate, detailing their structure, expression of CaBPs, and the impact of conditions like fetal hydrocephalus. The molecular layer is also examined, highlighting alterations in its organization due to genetic factors such as Trisomy 22. Further sections focus on the ganglionic eminence, discussing its developmental history, neuronal populations, and its importance in developmental neuropathology. The striatum is analyzed for its calbindin expression and the correlation with synapse-related proteins, emphasizing the implications for neuropathology. The amygdala's transient features and neuronal types are presented through immunohistochemical techniques. Additional areas covered include the basal nucleus of Meynert, hypothalamic tuberomamillary nucleus, and thalamic reticular complex, with attention to their neuronal characteristics and the effects of fetal hydrocephalus. The review concludes with a summary of findings and references, providing a detailed overview of the roles and significance of CaBPs across various brain regions in both development and pathology.

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• Année de publication: 2002