Growth factors and Alzheimer's disease

Auteurs

• Franz Hefti

Paramètres

• Santé & Médecine

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This comprehensive exploration delves into neurotrophic factors and their implications for neurodegenerative diseases. It examines the survival, regrowth, and reconnection of injured retinal ganglion cells, alongside the localization of nerve growth factor (NGF) family members in brain neurons. The annotation highlights studies on NGF's expression and actions within the central nervous system (CNS), including its gene expression in actively growing brain glia and its receptor expression in transgenic mice. Investigations into the role of protein kinase C in regulating NGF synthesis suggest potential links to impaired trophic supply in Alzheimer's disease. The distribution and characterization of NGF receptors in Alzheimer’s patients are discussed, along with cytokine regulation of NGF synthesis and its therapeutic implications. The annotation also addresses NGF's expression and function in the CNS, its role in behavioral recovery post-brain damage in rats, and the effects of dietary interventions on age-related functional impairments in nerve growth factor-sensitive neuronal projections. Further topics include the morphological and behavioral effects of fibroblast growth factors on transplanted neurons, the localization of these factors in the eye, and the development of synthetic peptide agonists and antagonists. Finally, it touches on the effects of neurotrophic factors on Alzheimer’s amyloid precursor metabolism and the com

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• Année de publication: 1991