Sudhir Paul Livres

The book addresses a significant gap in available resources for intermediate and advanced students, as well as practicing statisticians, by focusing on updated methods for inference with correlated data. It aims to provide comprehensive guidance on advanced statistical techniques, enhancing the understanding and application of these methods in various contexts. Through its targeted content, the book serves as a valuable tool for those looking to deepen their knowledge in this specialized area of statistics.

This volume addresses fundamental questions concerning the immunological genesis of the catalytic activity in antibodies, its relationship with classical antigen binding activity, and the biochemical mechanisms involved in catalysis. The contents reflect three main challenges in the field, i.e. to delineate the biological functions of catalytic antibodies in autoimmune disease; to isolate therapy-grade antibody catalysts with sufficient specificity and turnover to permit rapid removal of microbial and tumor antigens; and to develop immunogens that recruit immature catalyst-producing B cells into the clonal selection pathway and induce adaptive improvements of the catalytic function. Well-edited and up-to-date, this book reviews the current knowledge in the field and explores ways by which natural and engineered catalytic activities can be harnessed for medical applications. It should therefore be of special interest to immunologists, biochemists, biotechnologists, rheumatologists and pathologists.