Kapil Mehta Livres

The only book on insurance you'll ever need! We face risks without realising their enormity - death, accidents, ill-health, burglaries, earthquakes, riots, fires and storms. Additional risks, such as the Coronavirus, come about with alarming irregularity to disrupt our lives. Look around and you will see many examples of the deep impact these risks can have. A wage earner's premature death can put paid to their children's education; Chemotherapy can eat up your life's savings; an illness when overseas can leave you confused about how to get treated; heavy rains can flood your home; and an accident can cause litigation. Happily Insured provides an easy-to-understand, thoughtful approach to addressing those. The book is comprehensive, covering all your insurance needs (including those that you never imagined); practical and easy to understand. Insuring yourself carefully will give you the security and confidence needed to face the future. The confidence which is the secret to a happily insured life.

Transglutaminases are a family of enzymes found in diverse organisms, from bacteria to mammals and plants. They catalyze the formation of isopeptide bonds, which are highly stable and resistant to proteolytic degradation. These bonds play a crucial role in physiological processes, accumulating in hair and skin, and during wound healing, apoptosis, and blood clotting. Dysregulation of transglutaminase functions is linked to various pathological conditions, including neurodegeneration, autoimmune diseases, infectious diseases, progressive tissue fibrosis, and issues related to the epidermis's stratum corneum. Their ability to form stable isopeptide bonds is also utilized in food processing and the textile industry. Recent research has revealed their involvement in numerous biological processes, including cell growth, reproduction, and cell death. With the discovery of new transglutaminase family members and their functions, it is essential to compile these findings. This volume serves as a comprehensive resource for both new investigators and established researchers, focusing on the biological significance of transglutaminases in cancer, inflammation, autoimmune diseases, and related research areas.

In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observations a ligand for CD38 was recently identified and characterized. The natural ligand is capable of transducing signals similar to the agonistic antibody, following its interaction with cell surface CD38. Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome. This book offers the first single source on CD38 antigen and related molecules for new and experienced investigators. It will allow them to pose new and right questions in an attempt to elucidate the biological relevance and significance of these molecules in cancer, immunology, pharmacology and biochemistry.