Aslak Tveito Ordre des livres

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

When researchers gather around lunch tables, at conferences, or in bars, there are some topics that are more or less compulsory. The discussions are about the ho- less management of the university or the lab where they are working, the lack of funding for important research, politicians’ inability to grasp the potential of a p- ticularly promising ?eld, and the endless series of committees that seem to produce very little progress. It is common to meet excellent researchers claiming that they have almost no time to do research because writing applications, lecturing, and - tending to committee work seem to take most of their time. Very few ever come into a position to do something about it. With Simula we have this chance. We were handed a considerable annual grant and more or less left to ourselves to do whatever we thought would produce the best possible results. We wanted to create a place where researchers could have the time and conditions necessary to re?ect over dif?cult problems, uninterrupted by mundane dif?culties; where doctoral students could be properly supervised and learn the craft of research in a well-organized and professional manner; and where entrepreneurs could ?nd professional support in developing their research-based - plications and innovations.

In diesem Buch werden die Grundlagen partieller Differentialgleichungen sowie mit der Untersuchung numerischer Methoden für diese partiellen Differentialgleichungen in Zusammenhang stehende wichtige Überlegungen vorgestellt. Standardthemen wie Trennung der Variablen, Fourier Analysis, Maximumprinzipien und Energieabschätzungen werden behandelt. Numerische Verfahren werden parallel zur klassischen Theorie vorgestellt. Die Eigenschaften von Differentialgleichungen werden anhand numerischer Experimente veranschaulicht, und die Theorie der finiten Differentialapproximationen wird entwickelt. Numerische Verfahren werden eingeführt, um die Bedeutung des Rechnens bei partiellen Differentialgleichungen zu zeigen und die starke Interaktion zwischen mathematischer Theorie und der Entwicklung numerischer Verfahren zu illustrieren. Besonderer Wert wurde im gesamten Buch auf eine möglichst gleichgewichtige Darstellung der analytischen und der numerischen Verfahren gelegt.

This book teaches the basic methods of partial differential equations and introduces related important ideas associated with the analysis of numerical methods for those partial differential equations. Standard topics such as separation of variables, Fourier analysis, maximum principles, and energy estimates are included. Numerical methods are introduced in parallel to the classical theory. The numerical experiments are used to illustrate properties of differential equations, and a theory for finite difference approximations is developed. The text would be suitable for advanced undergraduate and graduate courses in mathematics and engineering. Necessary prerequisites for this text are basic calculus and linear algebra. Some elementary knowledge of ordinary differential equations is also preferable.