Peter K. Vogt Livres

General Description of the Volume: Oncogenes have become a central focus of cancer research. All involved in this discipline will find this volume an invaluable aid in developing protocols needed for their research. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Cell culture Molecular cloning Gene function Protein-protein interactions Protein-DNA interactions

This volume provides an overview of a diverse array of defective RNA's associated with virus infections. These agents span a continuum ranging from parasitic to synergic. They include defective molecules with relatively simple genome organizations that depend on all of the functions encoded by their helper viruses, as well as complexes consisting of defective virus-like components that require only a single gene necessary for a critical function. Individual chapters by selected authorities in the field discuss the biology of these agents, their roles in disease development, the structural features and replicative mechanisms characteristic of each defective entity, and the functions supplied by their helper viruses.

This volume constitutes a comprehensive collection of acticles on cyclin-dependent kinase inhibitors. The topics covered range from the basic biology and biochemistry of these proteins to their roles in development and carcinogensis. All the organisms where cyclin-dependent kinase inhibitors have been intensively studied, including yeast, mouse and man, are represented in the discussion. All of the articles have been contributed by experts in their respective discipline and provide up-to-date views of the field from the perspective of working scientists. As this is the first comprehensive volume strictly dedicated to the topics CDK inhibitors, it will be a valuable resource for anyone who needs or wishes to familiarize themselves with current thought on cell cycle regulation.

There are ominous signs that our defences against bacterial infections are crumbling. The past years have seen the emergence of superior pathogens that can no longer be controlled by antibiotics. We are in a race against microbial invaders. The challenge is to anticipate and respond to developments that affect the precarious balance between man and microbe. This volume presents articles from leading authorities on the frontiers of research probing molecular mechanisms of bacterial pathogenicity. Like many other areas of virology and medicine, this field has undergone a molecular and genetic revolution. Novel techniques and concepts are laying the groundwork for important advances in the control of bacterial disease.