Dario C. Altieri Livres

Details recent research on the ability of coagulation proteins/proteases to act as modulators of leukocyte effector functions, and potential implications in host defense and human disease. Coagulation is proposed as a response to injury, integrating the preservation of the hemostatic balance with host defense and immune-inflammatory responses. Part I introduces blood clotting mechanisms and their roles in leukocyte and vascular cell signaling. Part II describes the structure-function relationship of cellular receptors for blood clotting and examines fibrinolytic proteases and their role in signal transduction and effector cell responses. Distributed by Chapman & Hall. Annotation c. by Book News, Inc., Portland, Or.

This book critically reviews the most recent experimental advances on the cellular and molecular interface between coagulation and inflammation. Emphasis is placed on the structural and functional analysis of the molecules and receptors mediating the assembly of coagulation on leukocytes and on the functional and signaling consequences of these interactions. The overall goal is to provide an updated perspective on the emerging concept of leukocyte assembly of coagulation as a new signaling cascade participating not only in the hemostatic balance but also in the regulation of inflammatory and vascular cell responses.