Philip J. Farabaugh Livres

Focusing on the mechanisms of translation, this book delves into initiation, elongation, and termination processes in both prokaryotes and eukaryotes. It examines error correction during translation, highlighting the structural basis for these mechanisms and the role of ribosomes in maintaining fidelity. The text also explores frameshifting, distinguishing between spontaneous and programmed shifts, and discusses specific genes and systems, such as the pifE gene in E. coli and retrotransposons in yeast, that illustrate these concepts in action.

This book describes the phenomenology of several related unusual events which occur during protein expression from genes which include special sequences. These events, termed programmed alternative coding events, occur ubiquitously, including the AIDS retrovirus. The author explains the mechanisms underlying these unusual events in a large variety of genes, as well as the implications for gene expression in general, and carcinogenesis in particular.