Stefan H. E. Kaufmann Livres

The threat of infectious diseases has increased with globalization, and through history epidemics have eradicated whole regions, started vast migrations, and decided wars. This book looks at the conflict between rich and poor societies with regard to where outbreaks might occur and introduces possible strategies for containment.

Providing the latest information on preventive, diagnostic and therapeutic aspects of tuberculosis and AIDS, this is the only book to place a major emphasis on the increasing coexistence of these two life-threatening diseases in individuals. Edited by outstanding scientists in the field, this ready reference is divided into three main sections covering immunology and vaccination strategies, drugs, and clinical issues. Timely reading for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, as well as for the pharmaceutical and biotechnological industries.

The most urgently needed vaccines are those against poverty-related diseases such as tuberculosis, malaria and HIV. However, there is a considerable gap between the development of a vaccine and the implementation as a useful measure for disease control. Major obstacles need to be overcome even after successful completion of the preclinical stage. This book provides an important link between vaccine development and application under the particular conditions in developing countries. The editors, S. H. E. Kaufmann and P. H. Lambert – one from the field of basic research and the other an expert on the side of applied vaccinology – have gathered contributions from specialists of both fields in an attempt to create a source of information that has thus far not been available.

The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Tuberculosis remains one of the main fatal infections in humans. With annual morbidity and mortality rates worldwide of 8 and 2 million cases respectively, the disease is far from being eradicated. In fact, the dangerous liaison between TB and HIV, and the increasing incidences of multi-drug resistant strains of Mycobacterium tuberculosis are aggravating the problem. The latest epidemiological data indicate that new drugs and a novel vaccine are urgently needed to control TB adequately. This volume summarizes the state of the art in the prevention, diagnosis and therapy of TB. In addition, the molecular biology of M. tuberculosis and the immunology of the host response are presented. Researchers are beginning to understand how the immune response controls the pathogen quite efficiently, yet fails to eradicate it completely in the 2 billion people worldwide who are infected but do not develop the disease. Finally, recent strategies towards the development of new vaccines are reviewed. Scientists investigating the epidemiology, immunology and molecular biology of TB or engaged in vaccine and drug development as well as physicians and social workers treating TB patients will benefit from this timely overview.

A group of pathogens has chosen the interior of host cells as preferred biotope. These microbes cause infectious diseases of global importance such as tuberculosis, leprosy, typhoid, listeriosis, Legionnaire's disease, malaria, leishmaniasis, Chagas' disease and toxoplasmosis. Frequently, the course of infection is long-lasting eventually resulting in chronic disease. During their intracellular living, these pathogens intensively interact with parasitized host cells. Moreover, because of their intracellular life style these microbes are well shielded from humoral attack, and protection crucially depends on T lymphocytes. This volume provides an updated overview of the multifacetted crosstalk of intracellular pathogens with parasitized host cells and immune system.

Durch die Geschichte der Menschheit hinweg haben Infektionskrankheiten und Seuchen immer wieder ganze Landstriche ausgelöscht, Völkerwanderungen ausgelöst und Kriege entschieden. Doch auch und gerade heute im Zuge der zunehmenden Globalisierung unserer Welt, haben ansteckende Krankheiten nichts von ihrer Bedrohung verloren. Sie greifen in alle Bereiche unseres Lebens ein, sind Thema von Forschung und Medizin, prägen Gesellschaft und Kultur, beeinflussen Wirtschaft und Politik. In diesem Band wird nicht nur die Seuchengefahr in einer globalen Welt beschrieben, sondern auch Möglichkeiten und Strategien zu ihrer Eindämmung vorgestellt. Was können wir tun, um eine drohenden Gefahr zu vermeiden?

WAS SIE ÜBER IMPFEN WISSEN SOLLTEN Krankheitserreger sind unberechenbare Gegner. Die größte Hoffnung, sie einzuhegen, ruht auf den Impfungen. Von der Veröffentlichung des Erbguts des neuen Corona-Virus bis zur Bereitstellung einsatzbereiter Impfstoffe hat es kaum ein Jahr gebraucht – schon jetzt eine der größten Erfolgsgeschichten der Medizin. Der international renommierte Immunologe Stefan Kaufmann, selbst Entwickler eines Impfstoffs gegen Tuberkulose, schlägt den Bogen von der Geburtsstunde der Impfung vor mehr als 200 Jahren über die Ausrottung der Pocken bis zu neuesten Ansätzen für Impfstoffe gegen Krebs und setzt sich auch mit Impfrisiken und Impfgegnern auseinander.