Winfried G. Rossmanith Livres

This book focuses on hormones, and on how they are produced in very diverse regions of the body in humans and animals. But hormones can be found not only in vertebrates, but also in insects, shellfish, spiders, mollusks, even at the origin of metazoan diversification and exhibit the same pathways of synthesis. The book addresses the different classes of hormones: protein/peptides hormones, steroids and juvenile hormones and hormones like catecholamines, thyroid hormones and melatonin. It also discusses the types of hormone receptors, the majority of which are heptahelical G-protein coupled receptors or nuclear receptors. Particular attention is paid to the organs where hormones are created, with specifics on hormonal production and release, while a dedicated chapter details hormonal regulation from very simple to highly complex schemes. The remarkable kinetics of hormones production are also shown, before the book is rounded out by chapters on evolution in the endocrine system, the genetics of endocrine diseases and doping.

This comprehensive work explores the intricate relationships between sex steroids and various physiological processes. It begins with the androgen regulation of neuropeptide gene expression, followed by discussions on steroid modulation of gonadotropin-releasing hormone action in pituitary gonadotropes. The role of steroids and their receptors in brain tumors, particularly meningiomas, is examined, alongside the ultrastructural localization of estrogen-sensitive neurons in the rat forebrain. The text delves into the interplay between sex steroids and opioid peptides, as well as the impact of sex hormone-dependent brain organization on sexual behavior and ovarian function. It also highlights the actions of ovarian steroids on hypothalamic oxytocin and vasopressin expression, and how steroid hormones influence placental production of GnRH and CRF. Further, the book investigates a dopaminergic mechanism for estrogen regulation of hypothalamic β-endorphinergic activity, the involvement of catecholamines and amino acid neurotransmitters in GnRH pulse generation, and the pulsatile pattern of LH secretion relative to the sex steroid environment. It addresses the negative feedback control of gonadotropin secretion by estrogens and androgens across species, and the regulation of corticotrophin-releasing hormone release by steroids, with clinical implications. The work concludes with insights on the control of GnRH and gonadotropin s