Skin diseases and sexually transmitted infections represent 20% of all diagnoses in doctors' offices, posing a significant public health challenge in Europe. These conditions range from minor issues to severe diseases, including various cancers, infections, and chronic inflammatory diseases, all impacting patients' well-being and quality of life. The prevalence of skin cancers, allergies, chronic wounds, and sexually transmitted infections is rising, influenced by environmental factors and an aging population. Dermato-Venereologists face additional challenges due to the health burden from a growing number of refugees and migrants. The treatment of these conditions raises health economic concerns, especially with the advent of more effective but costly therapies for issues like psoriasis and melanoma. Timely diagnosis and treatment can reduce costs, lower morbidity, and enhance patients' quality of life, highlighting the importance of this medical field. The 5th edition of the EDF White Book details the burden of these diseases in Europe, variations in care and costs, and discusses prevention and management strategies. It includes a directory of national dermatological associations and patient organizations, serving as a valuable resource for health care policy decision-makers, medical professionals, and patients. Since its inception in 1997, the EDF has aimed to prevent skin diseases and improve care quality, and this edition
