Interacting protein domains
- 292pages
- 11 heures de lecture
This is the fourth NATO Advanced Study Institute focused on protein phosphorylation. The first meeting, titled "Signal Transduction and Protein Phosphorylation," occurred in September 1986 in Spezai, Greece. The second, held in September 1989 in Chateau La Londe, France, addressed "Cellular Regulation by Protein Phosphorylation," while the third meeting in September 1992 in Maratea, Italy, focused on "Tyrosine Phosphorylation/Dephosphorylation and Downstream Signaling." These titles reflect significant developments over the past decade. Initially recognized as central to signaling in 1990, protein phosphorylation was found to regulate various cellular processes. A new focus emerged on the role of growth factors and their corresponding receptors, which trigger protein tyrosine phosphorylation to control cell proliferation, a topic of the third meeting. Progress now hinges on understanding the three-dimensional structure of the proteins involved. For instance, determining the location of proteins through adaptor proteins relies on this structural knowledge. Consequently, the fourth meeting concentrated on the protein structure of signaling molecules and the principles of protein domain interactions, highlighting the importance of structural insights in advancing the field.
