This comprehensive guide covers the historical development and fundamental principles of the GC-MS technique, detailing sample preparation methods such as solid phase extraction, headspace techniques, and various pyrolysis methods. It explores gas chromatography, including sample inlet systems, carrier gas regulation, and injection techniques, along with chromatography parameters and the significance of chromatograms. The mass spectrometry section discusses ionization processes, reading mass spectra, and various analyzers, including the Orbitrap and Time-of-Flight analyzers. The evaluation of GC-MS analyses is detailed, focusing on chromatogram display, substance identification through mass spectra extraction and library searches, and quantitation methods, including standardization techniques and accuracy of analytical data. The applications section highlights diverse analyses, such as air quality testing, pesticide residue detection, and flavor profiling, showcasing the versatility of GC-MS in environmental and food safety contexts. Finally, the guide includes a glossary, further reading suggestions, and an index, making it a valuable resource for professionals and researchers in analytical chemistry and related fields.
