I. Klatzo Livres

Human greatness has many connotations. Since the requirements for membership in this category are vague and poorly defined, admittance to the Mount Olympus is frequently erratic and subjective, especially in view of a wide "penumbra zone"* of border cases. Nevertheless, rising above a twilight zone of debatable cases, there are individuals whose right for mem­ bership is unquestionable. In science, one of the unequivocal criteria for "greatness" relates to how far one's scientific achievement affects the opening of new horizons, and points to directions for future development and progress. Unveiling new visions can derive only from creative people who conceive original ideas and con­ cepts, and who are daring enough to promote them against the indifference or opposition of the establishment. Maintaining the integrity and the faith to one's own ideals may require extraordinary strength of character, - up to courting persecution or even death, - as happened in the middle ages, and more recently, in the first half of this century with regard to Cecile and Os­ kar Vogt, whose lives and accomplishments are described in this book. Thus the greatness of the Vogts is based both on their penetrating vision of the future for brain research and on the sterling quality of their character, which sustained a "test of fire" during the Nazi years in Germany.

Toxoplasmosis is a ubiquitous infection, contracted by at least a third of the population in most areas of the globe. Clinical disease arises rarely, usually unexpectedly, but sometimes with disastrous effects on the patient. Humans, pets, farm and zoo animals may contract toxoplasmosis, possibly involving any clinical laboratory in its diagnosis. Pathologists must ponder the clinical significance of a hyperplastic l. ymph node, a cyst found at autopsy, or a serologic titer. Serving as scientific physicians, pathologists are asked: How is toxoplasmosis diagnosed? 'What is the treatment for ocular toxoplasmosis, for congenital infection, or for toxoplasmosis in the immunologically compromised host? vVhy does disease develop in as diverse areas as the eye, lymph nodes and placenta? How is Toxoplasma transmitted? This review proposes to survey recent advances, providing a scientific background to diagnose and manage the clinical problems of toxoplasmosis. Reviews are available which emphasize other aspects, such as serologic pro­ cedures, resistance and immunity (REMINGTON, 1970), the clinical syndromes (DESMONTS, '1969; FELDMAN, 1968) and comprehensive presentations (JACOBS, 1967; FRENI{EL, '1970). Transmission and Prevalence The recent discovery of the coccidian stages of Toxoplasma in the cat intestine and the Toxoplasma oocyst excreted in cat feces, considerably broadens our understanding of Toxoplasma and its transmission (FRENKEL, DUBEY and MILLER, 1970). Inhaltsverzeichnis Penetration of the Intestinal Epithelium by Various Microorganisms..- Toxoplasmosis. Mechanisms of Infection, Laboratory Diagnosis and Management.- A Current Perspective of Monocytopoiesis.- The Pathogenesis of Thrombosis in Artificial Organs and Vessels.- Nuclear DNA Content of Human Myocardial Cells.- Author Index.