Akhlaq A. Farooqui Livres

The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.

Focusing on lipid mediators derived from glycerophospholipids, sphingolipids, and cholesterol, this book offers in-depth and current insights into their synthesis and degradation. It explores the critical role these lipids play in various neurological disorders, making it a valuable resource for understanding their biochemical pathways and potential implications in health and disease.

Focusing on glycerophospholipid and sphingolipid-derived lipid mediators, this book explores their role in cellular communication and neurological health. It highlights how these molecules function as both structural components of neural membranes and storage sites for lipid mediators. By consolidating scattered research findings, it offers a thorough examination of the generation and significance of these lipid mediators in various neurological disorders, making it an essential resource for understanding their complex involvement in brain health.

This comprehensive work delves into the underlying mechanisms of ischemic and traumatic injuries affecting the brain and spinal cord. It explores the biochemical and physiological responses to such traumas, highlighting potential therapeutic approaches. The text integrates recent research findings and clinical insights, making it a valuable resource for medical professionals and researchers interested in neuroprotection and recovery strategies. Emphasizing both the complexity of neural injuries and innovative treatment possibilities, it aims to enhance understanding and improve patient outcomes.

Exploring the role of phytochemicals, this book delves into their health benefits against oxidative stress and inflammation, particularly in neurological disorders. It discusses how these bioactive compounds, such as curcumin and resveratrol, influence cellular protection and stress-resistance through mechanisms like Nrf2 activation. The text emphasizes the importance of phytochemicals in promoting brain health from childhood to old age, potentially delaying age-related conditions like Alzheimer's and Parkinson's diseases. Comprehensive insights into their bioavailability and action in neurotrauma and neurodegeneration are also provided.

Focusing on the intricate links between metabolic syndrome and various health issues, this book delves into the relationships with stroke, Alzheimer's disease, and depression. It presents thorough research and insights that cater to postgraduate students, educators, researchers, pharmacologists, nutritionists, and medical professionals, making it a valuable resource for those seeking to understand these critical connections in health and disease.

The book offers in-depth insights into how diet, exercise, and sleep influence neuroinflammation and oxidative stress, focusing on both healthy brains and those affected by neurological disorders. It presents the latest research findings, making it a valuable resource for understanding the intricate connections between lifestyle factors and brain health.

The book delves into the molecular mechanisms underlying acute neural trauma and neurodegenerative diseases, emphasizing the chronic and progressive loss of neurons in specific brain regions. It offers extensive and up-to-date insights into the latest research, providing a thorough understanding of these complex conditions and their implications for treatment and prevention.

This book expands on the status and therapeutic importance of n-3 fatty acids and their mediators in normal brains and those with neurodegenerative and neuropsychiatric diseases. It also presents the benefits of n-3 fatty acids on the Western diet.

This book is the first to delve into the significance of curcumin in treating neurological disorders. With an estimated 35.6 million people affected by dementia globally in 2010, projections suggest this number could double every 20 years, potentially reaching 115.4 million by 2050. Alzheimer’s disease (AD), the primary cause of dementia, affects 60%–70% of those with the condition. Without breakthroughs in prevention or treatment, cases in the US alone may triple to 13.2 million by 2050. Therefore, exploring curcumin's role in delaying and treating AD is crucial. A healthy diet rich in curcumin, along with moderate exercise and adequate sleep, may enhance motor and cognitive functions, as well as address memory deficits associated with aging and AD. Regular curcumin consumption could alleviate some healthcare burdens by delaying AD's onset and progression. This volume offers a comprehensive and contemporary examination of curcumin's therapeutic potential in AD, based on cell culture and animal model research. It serves as a valuable resource for students, educators, researchers, dietitians, nutritionists, and physicians, and can supplement various neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists, and pharmacologists will benefit from insights into the molecular mechanisms of curcumin in AD treatment.