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This book introduces an innovative tool for synthesizing complex chiral structures in a single step. It compiles significant advancements in enantioselective one-, two-, and multicomponent domino reactions using chiral metal catalysts, covering literature since 2006. The text illustrates how these metal-catalyzed processes facilitate the development of diverse one-pot asymmetric domino reactions, enabling the generation of intricate products from simple materials. Adhering to Tietze's definition, it encompasses single-, two-, and multicomponent transformations. The content is organized into twelve chapters, focusing on various metal-catalyzed domino reactions involving copper, palladium, rhodium, silver, and others. Each chapter is structured into sections on one- and two-component reactions, followed by three-component processes, categorized by the nature of the reactions. Selected applications of these methodologies for synthesizing natural and biologically active products are included. The book showcases the combination of asymmetric metal catalysis with domino reactions, emphasizing high molecular complexity and enantioselectivity. It also highlights applications in the total synthesis of natural products, pharmaceuticals, and agrochemicals. Written by a leading expert, it will interest synthetic, organic, medicinal, and catalytic chemists in academia and R&D.

The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.