Arthur M. Lesk Livres

There are several ways to represent the structure of a protein, and sophisticated computer technology has been applied to provide them in visually exciting ways. Technical details of all of the known proteins have also been captured in the Brookhaven Protein Databank. What has been lacking isa manual that describes how to interpret and analyze these exciting pictures, and to understand what they show about the architecture of the protein. This book teaches the reader to look at protein structure diagrams and extract the meaningful information that they provide. It also contains acomplete atlas of all of the protein structures in the Brookhaven Protein Databank. Topics covered ball-and-stick models, shaded sphere models, schematic representations, tertiary structure and protein-ligand interactions, structure determination, and a wealth of information about therelevant computer systems.

Written primarily for students embarking on an undergraduate bioscience degree, this primer introduces students to the essential topics in protein science clearly and concisely by describing the basic chemical structure of proteins, the factors that stabilize protein structures, protein function, and protein evolution.

Introduction to Bioinformatics by Arthur Lesk is a timely and much-needed textbook which provides an accessible and thorough introduction to a subject which is becoming a fundamental part of biological science today. As a pioneer of the use of bioinformatics techniques in research, Dr Leskbrings unrivalled experience and expertise to the study of this field. The aim of the book is to generate an understanding of the biological background of bioinformatics, and to integrate this with an introduction to the use of computational skills. Without describing computer science orsophisticated programming skills in detail, the book supports and encourages the application of the many powerful computational tools of bioinformatics in a way that is both relevant to and stimulating for the reader.The book contains numerous problems and innovative Weblems (for Web-based Problems) to encourage students to engage with the subject and with the accompanying web site and to develop a working understanding and appreciation of the power of bioinformatics as a research tool.Web site www.oup.co.uk/best.textbooks/biochemi...