«Computational Genetics and Genomics: Tools for Understanding Disease surveys and assesses both currently available and powerful new computational genetic mapping methods that can be used to quickly analyze genetic models of biomedically important traits. This information provides a basis for uncovering the genetic factors regulating human disease-related traits.»-- Quatrième de couverture
This book provides a unique perspective on the rapidly advancing area of the pathogenetic mechanisms underlying human inflammatory disease, which has evolved from understanding the processes regulating leukocyte recruitment into inflamed tissues. Also unique to this book is a systematic examination of factors regulating organ-specific leukocyte recruitment. An attempt is made to determine whether in vivo data validates or indicates a need for changing generally accepted paradigms on the processes regulating leukocyte recruitment into inflamed tissues. Finally leukocyte recruitment is analyzed from a biomedical perspective: Will our current understanding of this process and our technological capabilities enable the development of clinically useful agents which selectively modulate leukocyte recruitment?