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The renin-angiotensin system (RAS) has traditionally been viewed primarily as a systemic endocrine system, with angiotensin II (ANG II) mainly regulating blood pressure and aldosterone release. Recent findings reveal that specific organ systems possess their own local RAS, operating largely independently of the systemic version. Over the past decade, extensive research has shown that ANG II has numerous functions beyond blood pressure regulation; it acts as a growth factor, exhibits profibrogenic properties, and functions as a proinflammatory cytokine. This peptide is crucial in the progression of chronic kidney disease towards end-stage renal failure, with clinical studies indicating that targeting ANG II can slow renal function deterioration. This publication offers the first comprehensive overview of these developments, reviewing both basic concepts and clinical implications of the RAS. International experts, who have made significant contributions to our understanding of ANG II's role in renal disease, provide insights. This work is essential reading for physicians managing chronic renal conditions, including internists, nephrologists, and urologists, as well as basic scientists like renal physiologists, pathologists, and biochemists seeking an in-depth understanding of the topic.
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The renin angiotensin system and progression of renal diseases, Wolf-Gunter Franke
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- Année de publication
- 2001
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