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Cancer can be tersely yet accurately described as improper cell proliferation. To understand cancer we must first understand the genetic and biochemical mechanisms responsible for proper cell proliferation. The last five years have witnessed the characterization of several families of novel proteins involved in cell cycle regulation and the clarification of the biochemical processes in which they participate. This book illuminates the roles of various cell cycle regulators - cyclins, cyclindependent kinases (CDKs) and CDK inhibitors - and describes the connections between these proteins and oncogenesis. Possible ways of clinical intervention that might be developed into potent cancer therapies are also explored. By chronologically documenting the discovery of cell regulators and providing clear, brief synopses of current findings, this work offers an easily accessible guide for both students and experienced researchers. An extensive list of excellent reviews for further reading rounds off the reference value of this timely publication.
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Cell cycle regulators in cancer, Kiran Musunuru
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- 1997
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